宗成利 博士 教授 博士生导师

  联系方式：海南省海口市人民大道58号伟德bv1946官网药学系，570228

  邮箱：chengli.zong@hainanu.edu.cn

  课题组：https://the_ring.gitee.io/zong-introduction/

  1.教育及工作背景

  2020.10-至今  伟德bv1946官网 教授

  2016.08-2020.10 默沙东制药公司-美国费城 高级科学家  

  2010.09-2016.05乔治亚大学（university of Georgia）-复杂碳水化合物研究中心（Complex Carbohydrate Research Center）（博士）

  2007.09-2010.07中国海洋大学-伟德bv1946官网（硕士）

  2003.09-2007.07中国海洋大学-伟德bv1946官网（本科）

  2.科研情况

  细菌疫苗新策略，新型肿瘤疫苗，疫苗佐剂活性增强研究

伟德bv1946官网-迈科康生物科技有限公司“先进疫苗研究联合实验室”-负责人

BV伟德国际1946-糖类小分子药物及多糖疫苗研究创新团队-负责人

3.研究领域

多糖疫苗，免疫学，药物化学，糖化员工物学

4.代表性项目

（1）肿瘤疫苗

新型原位肿瘤疫苗，基于肿瘤表面特殊抗原的亚单位疫苗。

（2）针对超级耐药菌的多糖疫苗研究

作为肺炎球菌多糖领域的行业专家，参与了默沙东下一代肺炎球菌疫苗的开发：例如细菌的发酵，荚膜多糖的分离，纯化，活化，与CRM197偶联等。参与研究的默沙东多价肺炎球菌结合型疫苗研发V114和V116项目已经进入临床实验。

（3）糖胺聚糖的化员工物学研究

建立了一种可以快速合成糖胺聚糖类化合物的保护基以及纯化策略，为此类化合物的构效关系研究奠定了基础。领导并完成了以下项目：建立了一个硫酸肝素四糖化合物库，通过微阵列筛选，发现了一系列硫酸肝素结合蛋白的底物特点；发现了一个在神经导向过程中起重要作用的硫酸肝素八糖结构；发现了一种可以修饰哺乳动物细胞表面的新方法；确定了肿瘤细胞表面一种特殊的硫酸软骨素A。

5.代表性成果

1）Teng, C-C.; Zong, C. *, “Self-assembled TLR7/8 agonist-mannose conjugate as an effective vaccine adjuvant for SARS-CoV-2 RBD trimer”, Polymers, 2022, 14, 5466 IF=4.967

2）Sun, T.; Mai, S-Y.; Mao, H-Z.; Li, H-T.; Duan, Y-Y.; Meng, S.; Bao, J-L.; Ding, N.; Zong, C.*, “Conjugate of Structurally Reassigned Pneumococcal Serotype 31 Polysaccharide with CRM197 Elicited Potent Immune Response.” Carbohydrate Polymers, 2022, 289, 119414 IF=10.72

3）Li, H-T.; Chen, C.; Mao, H-Z.; Xu, Y.; Meng, S.; Sun, T-T.; Zong, C. *, Efficient synthesis of α-galactosylceramide and its C-6 modified analogues, Frontiers in Chemistry, 2022, 1451 IF=5.221

4）Wan, Y.;* Zong, C.;*(共一) Li, X-P.; Wang, A.; Rodrigo, L-A.; Mao, C-B., “New Insights for Biosensing: Lessons from Microbial Defense System.” Chemical Reviews, 2022, 122, 8126-8180 IF=72.087

5）Zong, C.; Fang, L.; Song, F.; Wang, A.; Wan, Y., “Fluorescent Fingerprint Bacteria by Multi-channel Magnetic Fluorescent Nanosensor.” Sensors and Actuators B: Chemical. 2019, 289, 234-241. IF=9.221

6）Zong, C.; Venot, A., Li, X.; Lu, W; Xiao, W.; Wilkes, J-W; Salanga, C-L.; Handel, T-M.; Wang, L.; Wolfert, M-A.; Boons, G-J., “A Heparan Sulfate Microarray Reveals that Heparan Sulfate-Protein Binding Exhibit Different Ligand Requirements.” Journal of the American Chemical Society, 2017, 139, 9534-9543 IF=16.38

7）Zong, C.; Huang, R.; Condac, E.; Chiu, Y.; Xiao, W.; Li, X.; Lu, W.; Ishihara, M.; Wang, S.; Ramiah, A.; Stickney, M.; Azadi, P.; Amster, I-J.; Moremen, K-W.; Wang, L.; Sharp, J-S.; Boons, G-J., “Integrated Approach to Identify Heparan Sulfate Ligand Requirements of Robo1.” Journal of the American Chemical Society, 2016, 138, 13059-13067 IF=16.38

8）Zong, C.; Venot, A.; Dhamale, O-P.; Boons, G-J., “Fluorous supported modular synthesis of heparan sulfate oligosaccharides” Org. Lett., 2013, 15, 342–345. IF=16.38

9）Zong, C.; Li, Z.; Sun, T.; Wang, P.; Li, Y., “Convenient Synthesis of Sulfated Oligofucosides” Carbohydr. Res. 2010. 11, 1522-1532. IF=2.975

10）Lu, W.; Zong, C.; Liu, J.; Boons, G-J., “Controlled chemoenzymatic synthesis of heparan sulfate oligosaccharide.” Angewandte Chemie, 2018, 57, 5340-5344.

11）Yi, F.; Hong, X.; Kumar, A.B.; Zong, C.; Boons, G-J.; Scott, C.R.; Turecek, F.; Robinson, B.H.; Gelb, M.H., “Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry.” Molecular Genetics and Metabolism, 2018, 125, 59-63.

12）Moure, M.J.; Eletsky, A.; Gao, Q.; Morris, L.C.; Yang, J.Y.; Chapla, D.; Zhao, Y.; Zong, C.; Amster, I.J.; Moremen, K.W.; Boons, G-J., “Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1.” ACS chemical biology, 2018, 13, 2560-2567.

13）Capicciotti, C. J., Zong, C., Sheikh, M. O., Sun, T., Wells, L., & Boons, G-J. "Cell-Surface Glyco-Engineering by Exogenous Enzymatic Transfer using a Bi-Functional CMP-Neu5Ac Derivative." Journal of the American Chemical Society, 2017, 139, 13342-13348.

14）Agyekum, I.; Zong, C.; Boons, G-J.; Amster, I-J, “Single Stage Tandem Mass Spectrometry Assignment of the C-5 Uronic Acid Stereochemistry in Heparan Sulfate Tetrasaccharide using Electron Detachment Dissociation” Journal of the American Society for Mass Spectrometry, 2017, 29, 1-10.

15）Zhao, Y.; Singh, A.; Xu, Y.; Zong, C.; Zhang, F.; Boons, G.J.; Liu, J.; Linhardt, R.J.; Woods, R.J.; Amster, I.J., “A Traveling Wave Ion Mobility Spectrometry (TWIMS) Study of the Robo1-Heparan Sulfate Interaction” Journal of the American Society for Mass Spectrometry, 2017, 28, 96-109.

16）Huang, R.; Zong, C.; Venot A.; Chiu, Y.; Zhou, D.; Boons G-J.; Sharp, J., "The de novo Sequencing of Complex Mixtures of Heparan Sulfate Oligosaccharides” Analytical Chemistry, 2016, 88, 5299-5307

17）Gao, Q.; Chen, C.Y.; Zong, C.; Wang, S.; Ramiah, A.; Prabhakar, P.; Morris, L.C.; Boons, G.J.; Moremen, K.W.; Prestegard, J.H., “Structural Aspects of Heparan Sulfate Binding to Robo1–Ig1–2” ACS Chemical Biology, 2016, 11, 3106-3113.

18）Agyekum, I.; Patel, A-B.; Zong, C.; Boons, G-J.; Amster, J., “Assignment of Hexuronic Acid Stereochemistry in Synthetic Heparan Sulfate Tetrasaccharides with 2-O-sulfo Uronic Acids Using Electron Detachment Dissociation” International Journal of Mass Spectrometry, 2015, 390, 163-169.

19）Huang, Y.; Mao, Y.; Zong, C.; Lin, C.; Boons, G-J.; Zaia, J., “Discovery of a Heparan Sulfate 3-O-Sulfation Specific Peeling Reaction” Analytical Chemistry, 2015, 87, 592-600.

20）Hu, H.; Huang, Y.; Mao, Y.; Yu, X.; Xu, Y.; Liu, J.; Zong, C.; Boons, G-J.; Zaia, J., “A Computational Framework for Heparan Sulfate Sequencing Using High-resolution Tandem Mass Spectra” Molecular & Cellular Proteomics, 2014, 13, 2490-2502.

21）Dhamale, O-P.; Zong, C.; Al-Mafraji, K.; Boons, G-J., “New Glucuronic Acid Donors for the Modular Synthesis of Heparan Sulfate Oligosaccharides” Organic & Biomolecular Chemistry, 2014, 12, 2087-2098.

22）Zhang, Z.; Zong, C.; Song, G.; Lv, G.; Chun, Y.; Wang, P.; Ding, N.; Li, Y., “Total Synthesis of Caminoside B, a Novel Antimicrobial Glycolipid Isolated from the Marine Sponge Caminus Sphaeroconia” Carbohydr. Res. 2010, 6, 750-760.

23）Sun, T.; Zhang, W.; Zong, C.; Wang, P.; Li, Y., “First Total Synthesis and Stereochemical Reassignment of Tasiamide B” J. of Pept. Sci. 2010, 16, 364-374.